Adventures in Translocation: Studies of the Translocator Protein (TSPO) 18 kDa
نویسندگان
چکیده
The 18 kDa translocator protein (TSPO) is an evolutionarily conserved transmembrane found embedded in the outer mitochondrial membrane. A secondary target for benzodiazepine diazepam, TSPO has been a of interest researchers decades, particularly owing to its well-established links inflammatory conditions central and peripheral nervous systems. It become key biomarker assessing microglial activation using positron emission tomography (PET) imaging patients with diseases ranging from atherosclerosis Alzheimer’s disease. This Account describes research published by our group over past 15 years surrounding development ligands their use probing function this high-value target.
منابع مشابه
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ژورنال
عنوان ژورنال: Australian Journal of Chemistry
سال: 2021
ISSN: ['0004-9425', '1445-0038']
DOI: https://doi.org/10.1071/ch21176